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KMID : 0377519980230030121
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Chung-Ang Journal of Medicine
1998 Volume.23 No. 3 p.121 ~ p.128
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Cytogenetic defects in hematologic diseases
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Chae Seok-Lae
Cha Young-Joo
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Abstract
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Cytogenetic analyses of 218 patients with hematologic diseases and lymphoma were performed by MTx-treated high-resolution banding technique and the results were as follows. 1. Twenty three cases (58%) of 40 acute myelogenous leukemias revealed cytogenetic defects, and main defects were t(8;21), t(15;17), t(11q23;variable), -5, -7/del(7q), +8, and complex defects. 2. Seven cases (47%) of 15 lymphocytic leukemias revealed cytogenetic defects, and main defects were 5(9;22) and hyperdiploid chromosome. 3. In 20 cases of chronic myeloproliferative disorders, all of 7 chronic myelogenous leukemia had t(9;22). 4. Sixteen cases(63%) of 16 myelodysplastic syndromes revealed cytogenetic defects, and main defects were del(5q), -7, +8, and 5(5;12). The frequency of cytogenetic defects in the refractory anemia appeared high. According to the international prognostic scoring system(IPSS), 6 cases were classified as good, 7 cases as intermediate and 3 cases as poor karyotype group. 5. Other hematologic disease, lymphoma or multiple myeloma cases did not have disease-specific cytogenetic abnormalities. In conclusion, cytogenetic study plays an important role in the diagnosis and differential diagnosis of hematologic diseases as well as prediction of prognosis, and molecular study together with cytogenetic interpretation by skilled expert would raise sensitivity and specificity in the detection of genetic defects.
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KEYWORD
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cytogenetic, leukemia, myelodysplatic syndrome
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